Grey’s Anatomy may have seen Teddy take a decisive step in Season 21 by ending her complicated open-marriage entanglement with Sophia Bush’s unpredictable Cass, but with Season 22 set to premiere on ABC Thursday, Oct. 9 (10/9c), the possibility of rekindled sparks is very real.
Showrunner Meg Marinis teased to TVLine that it’s not hard to imagine the on-screen chemistry reigniting. “Oh, my gosh. I think it’s a very logical leap” to see these almost-lovers pick up where they left off, she said. “And Sophia is such a lovely person. We’d love to have her back.”
Fans remember that Cass brought a very different energy to Grey Sloan Memorial, standing out from the usual cast dynamics. Marinis is fully aware of the effect Bush has both on-screen and off. “Sophia’s an electric person. She brings a lot of energy to the scene,” she explained. “And the character we created for her has that same effect—whether she’s in professional or personal interactions. People are drawn to her, which makes writing those scenes really fun.”
Bush’s portrayal of Cass added a fresh, unpredictable element to the show, combining charisma with a certain wild streak that challenged the more grounded characters. It’s the kind of dynamic that writers and viewers alike find irresistible, and one that could open up new storylines for Teddy, especially as she navigates the personal and professional complexities of life at Grey Sloan.
Marinis hinted that the door isn’t just open—it’s practically swinging. The showrunners are clearly excited about the potential for Bush to return, which could mean more high-stakes drama, heartfelt moments, and witty banter between characters. And with Grey’s Anatomy always thriving on emotional tension and unexpected twists, bringing Cass back could be the perfect way to shake up Season 22.
Fans on social media have already speculated endlessly about what a reunion could look like. Would Teddy and Cass find a way to reconcile their differences, or will old tensions flare up in new and unpredictable ways? One thing seems certain: the combination of Bush’s charisma and the complicated dynamics of Grey Sloan Memorial is a recipe for memorable television.
So, Grey’s fans, what do you think? Is Cass a casual “nice-to-have” for the next season, or an absolute must-see? Do we 1,000% need Sophia Bush back in Grey’s Anatomy? Season 22 might just answer that question.